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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T24437 | MCP110 | MCP-110,MCP 110 | Raf , Ras |
MCP110 is an inhibitor of the interaction of Ras with Raf-1 and can be used in studies about the treatment of human tumors. | |||
T13114 | CCR2 antagonist 4 | Teijin compound 1 | CCR |
CCR2 antagonist 4 (Teijin compound 1) is a potent and specific antagonist of CCR2(IC50s of 180 nM), and potently inhibits MCP-1-induced chemotaxis(IC50 of 24 nM). | |||
T8316 | 1V209 | TLR7 agonist T7 | TLR |
1V209 (TLR7 agonist T7) is a Toll-like receptor 7 (TLR7) agonist and has anti-tumor effects. | |||
T11079 | NMI 8739 | n-docosahexaenoyl dopamine,Dha-DA conjugate | Dopamine Receptor |
NMI 8739 (n-docosahexaenoyl dopamine) is an agonist of D2 autoreceptor. NMI 8739 reduces NO production and elicits concentration-dependent suppression of CCL-20, MCP-1 and IL-6 release. | |||
T16091 | MK-0812 Succinate | Others , CCR | |
MK-0812 Succinate is an effective and selective CCR2 antagonist. It also has a high affinity at CCR2. | |||
T11648 | INCB 3284 | Others | |
INCB 3284, a potent and selective human CCR2 antagonist with an oral bioavailability, is utilized in the study of acute liver failure. It effectively inhibits the binding of monocyte chemoattractant protein-1 (MCP-1) to ... | |||
T19230 | CCR2 antagonist 4 hydrochloride | Teijin compound 1 hydrochloride | Others |
CCR2 antagonist 4 hydrochloride is a specific CCR2 antagonist (IC50s: 180 nM for CCR2b). It potently inhibits MCP-1-induced chemotaxis (IC50: 24 nM). | |||
T78806 | PPARδ agonist 9 | PPAR | |
PPARδ agonist 9 (compound 21), with an EC50 of 3.6 nM, is effective in vivo, decreasing serum MCP-1 concentrations in mice and markedly reducing atherosclerotic development in the LDLr-KO model with an inhibition rate of... | |||
T36130 | 22(S)-hydroxy Cholesterol | 22(S)-hydroxy Cholesterol,22β-hydroxy Cholesterol | |
22(S)-hydroxy Cholesterol is a synthetic oxysterol and a modulator of the liver X receptor (LXR). [1] t prevents monocyte chemoattractant protein 1 (MCP-1) expression induced by the LXR agonist GW 3965 in primary hepatoc... | |||
T80059 | Complement factor I | Endogenous Metabolite | |
Complement factor I, a serine protease, attenuates complement activity both in the fluid phase and on cell surfaces, working alongside cofactors such as factor H (FH), complement receptor 1 (CR1/CD35), C4 binding protein... | |||
T36198 | Avenanthramide-C methyl ester | ||
Avenanthramide-C methyl ester is an inhibitor of NF-κB activation that acts by blocking the phosphorylation of IKK and IκB (IC50 ~ 40 μM). Through this mechanism, avenanthramide-C methyl ester dose dependently inhibits t... | |||
T68721 | Cantharidin imide | ||
Cantharidin imide is a PP1/2A inhibitor found in Canarthis vesicatoria. It inhibits proliferation of colorectal cancer cells, increases MCP-1, IL-6, and IL-β levels, and inhibits differentiation and resorptive activity o... | |||
T82233 | HCAR2 agonist 1 | ||
HCAR2 agonist 1 (Compound 9n), a G i protein-biased allosteric modulator of HCAR2, activates the G i protein signaling pathway and exhibits anti-inflammatory properties by reducing mRNA levels of pro-inflammatory cytokin... | |||
T71884 | ß-Carboline-1-carboxylic acid | ||
β-Carboline-1-carboxylic acid is an alkaloid that has been found in P. quassioides and has diverse biological activities. It reduces LPS-induced increases in MCP-1, TNF-α, IL-6, and IL-1β levels in RAW 264.7 cells when u... | |||
T7499 | TAK-779 | Takeda 779 | HIV Protease , CXCR , CCR |
TAK-779 (Takeda 779) is an antagonist of chemokine receptor 5 (CCR5), CCR2b, and CXC chemokine receptor 3 (CXCR3). | |||
T11647 | INCB 3284 dimesylate | Others | |
INCB 3284 dimesylate is a selective and orally bioavailable human CCR2 antagonist, inhibiting monocyte chemoattractant protein-1 binding to hCCR2 (IC50: 3.7 nM). It can be used in the research of acute liver failure. | |||
T14845 | BX471 hydrochloride | ZK-811752 hydrochloride | Others |
BX471 hydrochloride (ZK-811752 hydrochloride) is a potent, selective non-peptide CCR1 antagonist (Ki: 1 nM for human CCR1). It shows 250-fold selectivity for CCR1 over CCR2, CCR5, and CXCR4. | |||
T37861 | Talabostat | ||
Talabostat (PT100, Val-boroPro) is a potent, nonselective and orally available dipeptidyl peptidase IV (DPP-IV) inhibitor with a Ki of 0.18 nM. Talabostat is a nonselective DPP-IV inhibitor, inhibiting DPP8/9, FAP, DPP2 ... |
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T6413 | Bindarit | AF2838 | CCR |
Bindarit (AF2838) displays specific inhibition against monocyte chemotactic proteins MCP-1/CCL2, MCP-3/CCL7 and MCP-2/CCL8. | |||
TC0036 | Compound Lup-20(29)-en-3-yl acetate | IL Receptor , VEGFR , Others , TNF , COX | |
Lupeol acetate, a derivative of Lupeol, inhibits the progression of rheumatoid arthritis by downregulating TNF-α, IL-1β, MCP-1, COX-2, VEGF and granzyme B. | |||
T4S0795 | Berberrubine chloride | 9-Berberoline Chloride,Beroline,Beroline Chloride,Berberrubine,9-Berberoline | IL Receptor |
1. Berberrubine chloride (9-Berberoline Chloride) has antitumor activity. 2. Berberrubine has antidiabetic activity. 3. Berberrubine dose-dependently inhibits IL-8 and MCP-1 protein levels in the media and mRNA expressio... | |||
T5688 | Micheliolide | NOS , NF-κB , COX | |
Micheliolide(MCL) is a sesquiterpene lactone which inhibits various inflammatory response. | |||
TN1154 | Nepetin | 6-Methoxyluteolin | Calcium Channel , Histamine Receptor |
Nepetin (6-Methoxyluteolin) has antioxidant activity, it is a potent inhibitor of histamine release and calcium influx via down-regulation of the FcεRI α chain. | |||
T4S0350 | Licochalcone B | Beta Amyloid , Others | |
1. Licochalcone B (LCB) inhibits the proliferation of human malignant bladder cancer cell lines (T24 and EJ) in vitro and antitumor activity in vivo in MB49 (murine bladder cancer cell line) tumor model. 2. LCB and Licoc... | |||
T38285 | C24:1 3'-sulfo Galactosylceramide (d18:1/24:1(15Z)) | C24:1 3'-sulfo Galactosylceramide (d18:1/24:1(15Z)) | Others |
C24:1 3'-sulfo Galactosylceramide (d18:1/24:1(15Z)) is the predominant sulfate analog in the mature myelin sheath. C24:1 3'-sulfo Galactosylceramide (d18:1/24:1(15Z)) interacted with C-type lectin and immunoglobulin-like... | |||
TN5593 | Euphohelioscopin A | ||
Euphohelioscopin A, an activator of protein kinase C (PKC), it inhibits proliferation and induces differentiation of the myeloid leukemia cell lines THP-1 and HL-60. Euphohelioscopin A has anti-inflammary activity, it ex... |
Cat No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-00118 | MCP-1/CCL2 Protein, Human, Recombinant (His) | Human | Yeast |
Monocyte chemoattractant protein 1 (MCP-1), also called CCL2, belongs to a group of CC chemokines located in chromosome 17q11.2. MCP-1 protein interacts with chemokine C-C motif receptor 2 (CCR2) to activate and recruit ... | |||
TMPK-00916 | MCP-1/CCL2 Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 |
Monocyte chemotactic protein-1 (MCP-1) (also referred to as chemokine (C-C motif) ligand 2 (CCL2) is expressed by mainly inflammatory cells and endothelial cells. MCP-1 has been reported to play an important role in the ... | |||
TMPY-00606 | MCP-1/CCL2 Protein, Mouse, Recombinant (His) | Mouse | Baculovirus-Insect Cells |
Monocyte chemoattractant protein 1 (MCP-1), also called CCL2, belongs to a group of CC chemokines located in chromosome 17q11.2. MCP-1 protein interacts with chemokine C-C motif receptor 2 (CCR2) to activate and recruit ... | |||
TMPY-05653 | MCP-1/CCL2 Protein, Mouse, Recombinant (His), Biotinylated | Mouse | Baculovirus-Insect Cells |
Monocyte chemoattractant protein 1 (MCP-1), also called CCL2, belongs to a group of CC chemokines located in chromosome 17q11.2. MCP-1 protein interacts with chemokine C-C motif receptor 2 (CCR2) to activate and recruit ... | |||
TMPK-00011 | MCP-1/CCL2 Protein, Human, Recombinant (His & Avi), Biotinylated | Human | HEK293 |
Monocyte chemotactic protein-1 (MCP-1) (also referred to as chemokine (C-C motif) ligand 2 (CCL2) is expressed by mainly inflammatory cells and endothelial cells. MCP-1 has been reported to play an important role in the ... | |||
TMPK-00010 | MCP-1/CCL2 Protein, Human, Recombinant (His & Avi) | Human | HEK293 |
Monocyte chemotactic protein-1 (MCP-1) (also referred to as chemokine (C-C motif) ligand 2 (CCL2) is expressed by mainly inflammatory cells and endothelial cells. MCP-1 has been reported to play an important role in the ... | |||
TMPY-01027 | Mast Cell Protease-1/MCPT-1 Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
Mast Cell Protease 1 (MMCP-1), also known as MCP-1, MCPT-1 and β-chymase, is a member of the Chymase family of chymotrypsin-like serine proteases. MCPT-1 is a 26 kDa β-chymase that is a component of mast cell granules. I... | |||
TMPK-00879 | CCR2b Protein-VLP, Human, Recombinant | Human | HEK293 |
The chemokine (C-C motif) receptor 2B (CCR2B) is one of the two isoforms of the receptor for monocyte chemoattractant protein-1 (CCL2), the major chemoattractant for monocytes, involved in an array of chronic inflammator... | |||
TMPJ-00852 | CCL2 Protein, Rat, Recombinant (His) | Rat | Human Cells |
Monocyte chemoattractant protein 1 (MCP-1), also called CCL2, is a member of the beta (C-C) subfamily of chemokines that is a chemoattractant for monocytes and basophils but not eosinophils or neutrophils. CCL2 binds the... | |||
TMPJ-00028 | CCL2 Protein, Mouse, Recombinant | Mouse | E. coli |
C-C motif chemokine 2 (CCL2) is a member of the C-C or β chemokine family. Mouse CCL2 shares 82% amino acid (aa) identity with rat CCL2 over the entire sequence, and 58%, 56%, 55%, 53% and 53% aa identity with human, equ... | |||
TMPY-00564 | MCP-4 Protein, Human, Recombinant (His) | Human | Yeast |
Monocyte Chemoattractant Proteins 4 (MCP-4/CCL13) is a member of a distinct, structurally-related subclass of CC chemokines mainly involved in recruitment of eosinphils to inflammatory sites. CCL13/MCP-4, is a CC family ... | |||
TMPJ-00009 | CCL2 Protein, Human, Recombinant | Human | E. coli |
The chemokine (C-C motif) ligand 2 (CCL2), also known as monocyte chemoattractant protein (MCP)-1 and small inducible cytokine A2 (SCYA2)), is a small cytokine that belongs to the CC chemokine family responsible for mono... | |||
TMPY-01774 | TREM-1 Protein, Human, Recombinant (His) | Human | HEK293 |
TREM1 (triggering receptor expressed on myeloid cells) is a type I transmembrane protein with a single Ig-like domain, and is selectively expressed on blood neutrophils and a subset of monocytes. As a member of the growi... | |||
TMPJ-00010 | CCL8 Protein, Human, Recombinant | Human | E. coli |
Human Chemokine (C-C Motif) Ligand 8 (CCL8) is produced by human MG63 osteosarcoma cells. CCL8 shares 62% and 58% amino acid sequence identity with MCP-1 and MCP-3, respectively. All three MCP proteins are monocyte chemo... | |||
TMPY-04671 | MCP-5 Protein, Mouse, Recombinant (His) | Mouse | Yeast |
Ccl12 prevented initiation of the reparative response by prolonging inflammation and inhibiting fibroblast conversion to myofibroblasts, resulting in diminished scar formation. Macrophage secretion of Ccl12 directly impa... | |||
TMPJ-00591 | CCL8 Protein, Human, Recombinant (His) | Human | Human Cells |
Human Chemokine (C-C Motif) Ligand 8 (CCL8) is produced by human MG63 osteosarcoma cells. CCL8 shares 62% and 58% amino acid sequence identity with MCP-1 and MCP-3, respectively. All three MCP proteins are monocyte chemo... | |||
TMPY-02023 | CD46 Protein, Human, Recombinant (His) | Human | HEK293 |
CD46, also known as Membrane Cofactor Protein (MCP), is a complement regulatory protein. CD46 is a type 1 membrane protein that plays an important inhibitory role in the complement system. CD46 is expressed in white bloo... | |||
TMPY-06527 | TREM-1 Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
TREM1 (triggering receptor expressed on myeloid cells) is a type I transmembrane protein with a single Ig-like domain, and is selectively expressed on blood neutrophils and a subset of monocytes. As a member of the growi... | |||
TMPJ-00968 | NAMPT Protein, Human, Recombinant (His) | Human | E. coli |
Pre-B cell colony enhancing factor (PBEF) was originally identified as a cytokine that potentiated the clonal expansion and differentiation of pre-B cells, but it is also acknowledged to be the ubiquitous intracellular e... | |||
TMPY-01887 | MCP-2 Protein, Human, Recombinant (SUMO) | Human | E. coli |
Chemokines are a family of small chemotactic cytokines, or proteins secreted by cells. Chemokines share the same structure similarities such as small size, and the presence of four cysteine residues in conserved location... | |||
TMPY-01866 | MCP-3 Protein, Human, Recombinant (His) | Human | E. coli |
Chemokines are a family of small chemotactic cytokines, or proteins secreted by cells. Chemokines share the same structure similarities such as small size, and the presence of four cysteine residues in conserved location... | |||
TMPY-00943 | TREM-1 Protein, Human, Recombinant (His & hFc) | Human | HEK293 |
TREM1 (triggering receptor expressed on myeloid cells) is a type I transmembrane protein with a single Ig-like domain, and is selectively expressed on blood neutrophils and a subset of monocytes. As a member of the growi... | |||
TMPY-04411 | YES1 Protein, Human, Recombinant (His & GST) | Human | Baculovirus-Insect Cells |
Proto-oncogene tyrosine-protein kinase Yes, also known as Proto-oncogene c-Yes, p61-Yes and YES1, is a cytoplasm protein that belongs to the protein kinase superfamily, Tyr protein kinase family and SRC subfamily. YES1 /... | |||
TMPY-04173 | MCP-3 Protein, Mouse, Recombinant (His) | Mouse | E. coli |
Chemokines are a family of small chemotactic cytokines, or proteins secreted by cells. Chemokines share the same structure similarities such as small size, and the presence of four cysteine residues in conserved location... | |||
TMPY-04680 | MCP-2 Protein, Human, Recombinant (His) | Human | Yeast |
Chemokines are a family of small chemotactic cytokines, or proteins secreted by cells. Chemokines share the same structure similarities such as small size, and the presence of four cysteine residues in conserved location... | |||
TMPY-04451 | AMPK (G1/B1/A1) Heterotrimer Protein, Human, Recombinant (His & GST) | Human | Baculovirus-Insect Cells |
AMPK (G1/B1/A1) Heterotrimer Protein, Human, Recombinant (His & GST) is expressed in Baculovirus-Insect Cells | |||
TMPY-03878 | Integrin alpha V beta 6 Protein, Human, Recombinant (Flag & His) | Human | HEK293 |
Integrin alpha-5, also known as ITGA5, is a single-pass type I membrane protein which belongs to the integrin alpha chain family. ITGA5 contains 7 FG-GAP repeats. Alpha chain 5 undergoes post-translational cleavage in th... | |||
TMPY-02501 | CD3D & CD3E Heterodimer Protein, Human, Recombinant | Human | HEK293 |
CD3D & CD3E Heterodimer Protein, Human, Recombinant is expressed in HEK293 cells. | |||
TMPY-03745 | CD3D & CD3E Heterodimer Protein, Human, Recombinant (Flag & His) | Human | HEK293 |
CD3D & CD3E Heterodimer Protein, Human, Recombinant (Flag & His) is expressed in HEK293 with Flag and His tag. The predicted molecular weight is 31.05 kDa. Accession number: P04234-1&P07766-1 | |||
TMPY-02794 | TLR2 Protein, Human, Recombinant (aa 1-587, His) | Human | Baculovirus-Insect Cells |
TLR2, also known as CD282, is a member of the Toll-like receptor (TLR) family. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They play a fundamental role in pathoge... | |||
TMPY-03947 | CD48 Protein, Human, Recombinant (hFc) | Human | HEK293 |
Cluster of Differentiation 48 (CD48), also known as SLAMF2, BCM-1 and BLAST-1, is a GPI-linked protein belonging to the CD2 subfamily of immunoglobulin superfamily molecules. CD2 and 2B4 (CD244) are known ligands for CD4... | |||
TMPY-03481 | IL-1R2 Protein, Human, Recombinant | Human | HEK293 |
Interleukin 1 receptor, type II (IL1R2) also known as CD121b (Cluster of Differentiation 121b) is a cytokine receptor that belongs to the interleukin-1 receptor family. This protein binds interleukin alpha (IL1A), interl... | |||
TMPK-00114 | C-Reactive Protein /CRP Protein, Human, Recombinant (His) | Human | HEK293 |
C-reactive protein (CRP) is a polypeptide molecule belonging to the family of pentraxins. CRP is synthesized primarily by the liver in response to certain pro-inflammatory cytokines. It plays an important role in innate ... | |||
TMPY-00740 | SDF-1 Protein, Human, Recombinant (hFc) | Human | HEK293 |
The human stromal cell-derived factor-1 (SDF1), also known as CXCL12, is a small (8 kDa) cytokine highly conserved chemotactic cytokine belonging to the large family of CXC chemokines. SDF1 is expressed in two isoforms f... | |||
TMPY-04384 | Src Protein, Human, Recombinant (His & GST) | Human | Baculovirus-Insect Cells |
Proto-oncogene tyrosine-protein kinase SRC is a hydrophobic protein belonging to the SRC family kinase including nine members that is a family of non-receptor tyrosine kinases. SRC protein may exist in different forms: C... | |||
TMPK-01151 | MXRA8 Protein, Human, Recombinant (His) | Human | HEK293 |
Mxra8 is a recently described receptor for multiple alphaviruses, including Chikungunya (CHIKV), Mayaro (MAYV), Ross River (RRV), and O'nyong nyong (ONNV) viruses. | |||
TMPK-01074 | CD163 Protein, Human, Recombinant (His & Avi) | Human | HEK293 |
The hemoglobin (Hb) scavenger receptor, CD163, is a macrophage-specific protein and the upregulated expression of this receptor is one of the major changes in the macrophage switch to alternative activated phenotypes in ... | |||
TMPK-00383 | ACE2/ACEH Protein, Human, Recombinant (His & Avi) | Human | HEK293 |
ACE2 (Angiotensin I Converting Enzyme 2) is a Protein Coding gene. Diseases associated with ACE2 include Severe Acute Respiratory Syndrome and Neurogenic Hypertension.The protein encoded by this gene belongs to the angio... | |||
TMPY-02525 | RGMA Protein, Human, Recombinant (His) | Human | HEK293 |
RGMa, also known as RGM domain family, member A, belongs to the RGM (repulsive guidance molecule) family whose members are membrane-associated glycoprotein. RGMa is a glycosylphosphatidylinositol-anchored glycoprotein th... | |||
TMPY-04753 | IRE1 Protein, Human, Recombinant (aa 465-977) | Human | Baculovirus-Insect Cells |
Endoplasmic reticulum stress and hypoxia are necessary components of malignant tumors growth and suppression of ERN1 (from endoplasmic reticulum to nuclei-1) signalling pathway, which is linked to the apoptosis and cell ... | |||
TMPY-04413 | IRE1 Protein, Human, Recombinant (aa 465-977, His & GST) | Human | Baculovirus-Insect Cells |
Endoplasmic reticulum stress and hypoxia are necessary components of malignant tumors growth and suppression of ERN1 (from endoplasmic reticulum to nuclei-1) signalling pathway, which is linked to the apoptosis and cell ... | |||
TMPK-01393 | Tenascin Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
Tenascin-C (TNC) is a hexameric, multimodular extracellular matrix protein with several molecular forms that are created through alternative splicing and protein modifications. It is highly conserved amongst vertebrates,... | |||
TMPK-00305 | TGFBR1 Protein, Human, Recombinant (mFc & Avi) | Human | HEK293 |
transforming growth factor beta receptor 1 (TGFBR1), a key stimulator of tumor proliferation and metastasis, was a direct target of miR‑98‑5p. miR‑98‑5p overexpression resulted in the downregulation of TGFBR1 and the sup... | |||
TMPY-01460 | ABHD4 Protein, Human, Recombinant (His) | Human | Baculovirus-Insect Cells |
Abhydrolase domain containing 4 (ABHD4), also known as alpha/beta-hydrolase 4 (ABH4) , or lyso-N-acylphosphatidylethanolamine lipase, which belongs to the ABHD4/ABHD5 subfamily of peptidase S33 family. Abhydrolase domain... | |||
TMPY-00978 | Progranulin Protein, Human, Recombinant (His) | Human | HEK293 |
Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The precursor protein, progranulin, ... | |||
TMPY-02227 | IL-1 beta/IL-1F2 Protein, Rat, Recombinant (mature form) | Rat | E. coli |
Interleukin-1 beta (IL1 beta or IL1B) also known as catabolin, is a member of the interleukin 1 cytokine family. IL1 is a pleiotropic cytokine. It is involved in the inflammatory response, cell growth, and tissue repair ... | |||
TMPY-05526 | Siglec-15 Protein, Human, Recombinant (His) | Human | HEK293 |
Siglec-15 Protein, Human, Recombinant (His) is expressed in HEK293 cells. | |||
TMPY-01963 | IL-21 Protein, Human, Recombinant | Human | E. coli |
IL21 belongs to the IL-15/IL-21 family. It is a cytokine with immunoregulatory activity. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellul... | |||
TMPY-05781 | LILRA6 Protein, Human, Recombinant (His) | Human | HEK293 |
LILRA6 Protein, Human, Recombinant (His) is expressed in HEK293 with His tag. The predicted molecular weight is 47.78 kDa. Accession number: Q6PI73-1 | |||
TMPY-06077 | LILRA1/LIR-6/CD85i Protein, Human, Recombinant (hFc) | Human | HEK293 |
LILRA1/LIR-6/CD85i Protein, Human, Recombinant (hFc) is expressed in HEK293 with hFc tag. The predicted molecular weight is 75.3 kDa. Accession number: O75019-1 | |||
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